Central Clinical Trials Register

Support for a clinical research

© corbis_fancy/fotolia.com

Clinical trials are essential for developing new treatment methods that improve the recovery chances of cancer patients. The Central DKTK Trials Register offers patients and attending physicians a simple way of obtaining an overview of the oncological trials currently accepting patients at the DKTK locations. A search function lets users find the appropriate trials for them.

All DKTK locations are involved in developing the trials register. The focus is on treatment trials testing new active pharmaceutical ingredients or new surgical or radiotherapy methods. Some of the treatment concepts are led by the DKTK locations themselves as academic, investigator-initiated trials, and some selected trials are conducted by other sites with the participation of DKTK locations. Information on the various types of trial and on the opportunities and risks of trials, can be found on the DKFZ Cancer Information Service website.

The register itself consists of a concentrated metadata set of treatment trials from the registers at the individual locations. The locations share a very limited set of trial profile data (standard register dataset). The CCP Office provides a revision and quality assurance service for the trial profile data and adds relevant search parameters.

A search screen lets users search the database for tumor types, but also for relevant molecular markers for a particular tumor, lines of treatment and other parameters, and to see the matching, active trials and the lead physicians responsible for them at the locations in question. The trials on the website are also linked to the trial registers at the DKTK locations, making it easy for users to obtain further information on the individual trials. The local registers at the DKTK locations contain additional trials that don’t appear in the central register.

The data in the DKTK Trials Register is updated quarterly: new trials are added and any that have closed are marked accordingly. In some cases, therefore, a trial may still be marked as ‘open’ when patient recruitment has closed.

Cancer patients and their relatives who want to find out about clinical trials using the trials register should always discuss the information with their attending physician before approaching the lead trial physician. The attending physician will know the details of the clinical situation and will be able to give further advise on what to do next.​

Publications to the trials register:

Ihrig, K. et al. (2018). Das DKTK-Studienregister: Die zentrale Informationsplattform für Therapiestudien onkologischer Spitzenzentren der Krebsmedizin. In: ONKOLOGIE heute, Oktober 2018. To the article

Four basic search hints

  1. You can search for specific trials in stages, moving from a general overview to more detailed descriptions. Starting with the general type of cancer, you can move on to the next level with specific tumor types. From there, you can see more overviews offering trials for first-line treatment or second-line and subsequent treatment for patients with this type of tumor. Clicking on the short title brings up the summary of the specific trial, with the trial profile data, contact details and active links to other registers with detailed criteria for inclusion and exclusion. This overview is available as a PDF.
  2. You can filter your search by selecting criteria from a number of lists. Using this detailed search you can select criteria such as the type of cancer, the type of tumor, the type of treatment, the trial status, trial locations and the molecular target structures or patient groups with particular molecular markers. The search results are presented in a list of trials (short titles) that match your criteria. Clicking on the short title brings up the summary of the trial, with the trial profile data, contact details and active links to other registers with detailed criteria for inclusion and exclusion. This overview is available as a PDF.
  3. After carrying out a search, especially a detailed search, you can always start another search by clicking on the “DKTK Clinical Trials Register” heading.
  4. Searching for molecular markers:
    When you carry out a detailed search for a molecular marker, it may not appear in the selection menu. There are two possible reasons for this. It may be that the marker is not being investigated in any trials or that it does not represent a criterion for inclusion in the trial.
    Or it may be that the marker has not been entered in the list under the name you are looking for. Sometimes, molecular markers are known by more than one name.
    The DKTK trials register aims to harmonize terminology. For this reason, the trials register uses the gene names from the internationally recognized HGNC Gene Nomenclature. Examples include: PDL1 (Hugo: CD274), MEK (Hugo: MAP2K1).
    Further information (including synonyms of gene names) can be found in the HGNC database.


For further information, please contact Zenawit Krüger (krueger@med.uni-frankfurt.de).

CCP Trials Register experts

  • Dr. Susen Burock (Berlin)
  • Dr M. Wermke, M. Falk, MBA (Dresden)
  • Dr Stefan Palm (Essen)
  • Dr Sina Hehn (Frankfurt)
  • Dipl.-Biol. Christina van Oordt (Mainz)
  • Dieter Batz, Dr Olga Grishina (Freiburg)
  • Prof Dr Richard Schlenk, Dorothea Beck (Heidelberg)
  • Dr Christiane Blankenstein  (München, TUM), Dr Daniel Nasseh (München, LMU), Anna Vetter (München, LMU)
  • Dipl.-Volksw. Andrea Seckinger (Tübingen)