UPGRADE CALL 2021

8. DKTK Joint Funding call “UPGRADE” from January 2021 is completed!

With the Joint Funding line “UPGRADE” DKTK supports existing (mono‐ or multicenter) IITs/clinical studies with (limited) “add‐on” funding for a collaborative complementary research module performed by DKTK scientists for up to 3 years.

12 research proposals were submitted in this call. In June 2021, four projects were selected for a respective 3-year funding in the DKTK Joint Funding Program:

  • AMPLIFY IMMUNOLOGICAL INSIGHTS BY GLIOMA ORGANOIDS (AMI2GO): Insights into mechanisms of T cell response and resistance in post-treatment multicellular AMPLIFY NEOVAC glioma organoids. Underlying study: AMPLIFY-NEOVAC (NOA-21, ClinicalTrials.gov Identifier: NCT03893903)

Overall Coordinator: Prof. Michael Platten, Heidelberg

Participating DKTK sites: Berlin, Frankfurt/Mainz, and Heidelberg

            Project start: September 2021

  • PREDICTIVE BIOMARKER FOR ADJUVANT IMMUNOTHERAPY (IMMUNED): Integrative molecular and functional analysis of tumor, tumor microenvironment and antitumor immune responses for correlation with clinical outcome of adjuvant immune checkpoint blockade in stage IV melanoma. Underlying study: IMMUNED (EudraCT No.: 2014-001167-12)

Overall Coordinator: Prof. Jürgen C. Becker, Essen

Participating DKTK sites: Essen/Düsseldorf, Heidelberg, and Tübingen

Project start: July 2021

  • PERSONALIZED TERTIARY CANCER PREVENTION (PEVIDS): Impact of personalized vitamin D supplementation on the immunome and proteome of colorectal cancer patients: potential for personalized tertiary prevention. Underlying study: VICTORIA (EudraCT No.: 2019-000502-30)

Overall Coordinator: Prof. Hermann Brenner, Heidelberg

Participating DKTK sites: Heidelberg, München, and Tübingen

            Project start: July 2021

  • NEOANTIGEN RECOGNITION BY VACCINE-INDUCED T CELLS (IVAC-AN): Analysis of neoantigen distribution, presentation and recognition by vaccine-induced specific T cells. Underlying study: IVAC-ALL-1(EudraCT No.: 2015-005281-29)

Overall Coordinator: Prof. Peter Lang, Tübingen

Participating DKTK sites: Berlin, Essen/Düsseldorf, München, and Tübingen

Project start: September 2021

 

More detailed project descriptions will soon be available here